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The light chain of the xCT protein and histone acetyltransferases (HATs) are distinctly homogeneous, and the HATs are a family of amino acid transporters that are linked by the light chain and the heavy chain through disulfide bonds (Wang et al., 2003
All experimental procedures involving animals were conducted following international recommendations for the care and use of laboratory animals, as well as the guidelines of the Brazilian Society of Neurosciences and Behavior for Animal Care
Individual experiences vary, and specific results cannot be guaranteed
The predominantly alpha-helical C-terminal domain is involved with the binding of hydrophobic substrates (such as hydrophobic portions of xenobiotics)
This cascade leads to a significant increase in TFR1 and Fe 2+ levels, promoting neuronal ferroptosis and lipid peroxidation, which exacerbates muscle atrophy and motor dysfunction in mice
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