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Hypotension (may cause vasodilation through nitric oxide modulation)

Incretin therapy: should adverse consequences have been anticipated

Furthermore, with a run-in phase of a low-calorie diet, total weight loss of up to 12.5 kg can be achieved (of which half [6.2%] was observed during the liraglutide 3.0 mg treatment period) in subjects with obesity (176)

We are confident in this timing and coverage expansion because we believe the administration is highly motivated to increase GLP-1 access before the midterm elections

But it is an important consideration, given that the research published so far shows that when patients discontinue using these medications, their appetite returns, and the majority regain some or all of the weight they initially lost