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Furthermore, the strong sequence homology within the catalytic core contributes to substantial challenges in achieving isoform-selective inhibition and often results in off-target engagement, a major factor underlying the clinical failure of PDE-targeted therapeutics (Goff et al., 2009
Beyond GSH, structures of Cys-GSTs with physiological substrates have been obtained in rare cases
Strong insurance coverage and government initiatives aimed at addressing the obesity epidemic further support market growth
That may be because more women experience constipation than men, which may in turn lead to more laxative use
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