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For the trial product estimand, a closed testing procedure was used to control the overall type 1 error at a nominal two-sided 5% level
There is no established pharmacological mechanism by which tirzepatide would directly increase or decrease sexual desire
Leptin mRNA and leptin have been detected in the main cells of the stomach mucosa and in the gastric fundus [23]
But new research on a rare yet devastating side effect may deter some prospective GLP-1 seekers: hair loss
Many commercial insurance plans now cover GLP-1 medications like semaglutide and tirzepatide for diabetes but may require prior authorization for weight loss use
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