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Finally, GSH deficiency contributes to oxidative/nitrosative stress, a condition actually connected with the pathogenesis of many diseases, including cancer, diseases of aging, cystic fibrosis, infection and neurodegeneration

Can SAH be elevated when homocysteine is normal

These observations suggested that GSH depletion induces SIPS in RPE cells

Clinical trial design must account for this heterogeneity, possibly incorporating patient stratification based on imaging, genetic risk factors (e.g., APOE or TREM2 variants), or peripheral cytokine profiles

Overall, ROS accumulation in conjunction with declining antioxidant defenses may contribute to oocyte and granulosa cell dysfunction and influence the aging trajectory of the follicular microenvironment