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Although nausea and diarrhea were the most frequent side effects associated with semaglutide, they were often mild to moderate in intensity and eventually went away

These drugs were first approved in diabetes under brand names Ozempic and Mounjaro, respectively

It was also a requirement that they had taken a psychedelic at some point in their life, partly because they were taking a high dose, equivalent to 5g of magic mushrooms, and they were getting into a big, loud, banging, claustrophobic magnet [while] on psilocybin, said Siegel, adding the team needed to be sure participants would be able to tolerate the situation

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Moreover, a repeated liraglutide treatment regimen was used to better mimic clinical conditions, as significant therapeutic effects in chronic disorders such as addiction are rarely observed after a single exposure