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The Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) tool was used to assess the certainty of the evidence for the two primary biochemical outcomesserum vitamin B12 concentration increase and homocysteine reductionacross all included studies, and separately for randomised controlled trials (RCTs) and observational studies
Remember, theres no such thing as a wonder drug
If Wegovy does not produce a clinically meaningful weight loss after an appropriate trial at the maintenance dose, your healthcare provider may recommend reviewing or discontinuing treatment and discussing alternative weight management options
Two-sided Pearson correlation test is applied and p-values adjusted by Benjamini-Hochberg
Garvey, R
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