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(2) ROS activates NF-B and MAPK signaling pathways, upregulating the expression of MMPs (MMP-13, MMP-3) and inflammatory factors (IL-1, TNF- ), thereby accelerating the degradation of type II collagen (Col-II) and proteoglycans
Agliardi C, Guerini FR, Saresella M, et al
It does not require a cover-up
doi: 10.1001/jama.2010.490
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