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Furthermore, it has been indicated that their deficiency is linked to reduced DNA methylation due to the disruption of DNMT enzymes 33,34

ROS can be regulated by glutathione peroxidases (GPxs), which are the key enzymes that maintain ROS homeostasis in vivo through the reduction of ROS [10]

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Notably, serum tGSH (but not serum cystine) levels were lower in mice with tumours than in mice without tumours (Extended Data Fig