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These preclinical results were supported by genome-wide association studies, which have identified variants with reduced activity at the human GIP receptor locus that are associated with reduced BMI [72]

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However, when levels are too high for a long time, it results in leptin resistance, which is a state where the hormone is no longer effective at regulating hunger

Yes, some medical issues like Addisons disease and Peutz-Jeghers syndrome can cause lip color changes