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The chemicals present in tobacco smoke can inhibit DNA repair enzymes, such as DNA polymerases and DNA repair proteins 112
doi: 10.1080/15384101.2019.1638190 84 PanXGongNZhaoJYuZGuFChenJet al
So, for women who are following Hormone Replacement Therapy (HRT) by taking a pill, the decreased absorption of the drugs can actually cause a sudden (but unwanted) drop in estrogen causing mood swings and hot flashes to unexpectedly return
Lab Invest 94: 63-78, 2014
Therefore, its common for vegetarians and vegans to have a deficiency
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