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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-

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Metformin and fluoxetine improve depressive-like behavior in a murine model of Parkinsons disease through the modulation of neuroinflammation, neurogenesis and neuroplasticity

The ADVISE trial attempted to establish a biomarker-guided allocation algorithm for combination immunotherapy, although it achieved treatment matching within 12 days for 87% of patients, it completely failed to predict outcomes in PD-1 resistant populations, with a treatment response rate of zero, highlighting the challenges posed by the dynamic TME for precise modeling (318)