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Call your clinician for severe or persistent abdominal pain, signs of dehydration you cannot correct, or any symptom that worries you
Their additional concern is the psychological impact
Maintain adequate hydration (1.52 litres daily), eat small frequent meals, rise slowly from sitting or lying positions, and monitor blood glucose levels if taking insulin or sulfonylureas
EMA decision P/0336/2024 paediatric investigation plan for retatrutide
The rationale is straightforward: a 120kg individual has significantly more tissue volume for the peptide to distribute through than a 70kg individual, which affects both the effective concentration at receptor sites and the perceived intensity of side effects
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