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Implications for protein architecture, substrate recognition and catalytic function
It is also reported that the 17-hydroxysteroid dehydrogenases HSD17B1, HSD17B5, and HSD17B7 catalyze the C3 hydroxy oxidation ( FIGURE 7 The double-bond isomerization following 3-hydroxy oxidation in the steroids is conventionally ascribed to an ancillary function of the dehydrogenase, displaying 3-ketosteroid isomerase activity in addition to the redox catalysis
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