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Indeed, high NAD + levels and NAD + /NADH ratios are associated with increased energy production in humans, improved mitochondrial membrane potential, and decreased mitochondrial mass through mitophagy in vitro, suggesting improved efficiency of mitochondria 94,95,96,97

These treatments, which included crude preparations of animal thyroid extracts, were moderately effective but led to cardiac arrhythmias and hyperthyroidism

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Its FDA-approved for reducing visceral adipose tissue, particularly in HIV-associated lipodystrophy, but its effects translate well for general fat loss in the abdominal region

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