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monitor glucose carefully) Possible increase in heart rate Gallbladder issues (contact pharmacy if sudden pain or fever) Risk of thyroid C-cell tumours (avoid if personal/family history of medullary thyroid carcinoma) If you develop severe abdominal pain, persistent vomiting, or signs of an allergic reaction, seek urgent NHS medical advice

Active or recent pancreatitis contraindicates use

Notably, the observed reductions in the odds of substance use disorders, including a 74% decrease in the odds of AUD, a 69% reduction for OUD, a 68% reduction for NUD, and a 75% reduction for CUD, among GLP-1 RA users were consistent with emerging preclinical and clinical studies showing that GLP-1 RA modulates reward pathways in the brain to reduce SUD (17, 23)

Comorbidity management may extend or shorten treatment duration

in 2017, in which the presence of the enzyme itself promoted wound-healing