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This careful titration schedule allows your body to adapt to the medication while minimizing the gastrointestinal side effects that plague aggressive dosing approaches
"Design, Synthesis and Biological Evaluation of Neogliptin, a Novel 2-Azabicyclo[2.2.1]heptane-Based Inhibitor of Dipeptidyl Peptidase-4 (DPP-4)"
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On one hand, it specifically activates the TLR2/NF-B signaling pathway [89], upregulates the expression of tight junction proteins, thereby effectively reducing intestinal permeability [25, 90, 91]
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