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Reduced glutathione (GSH) is oxidized to glutathione disulfide (GSSG) in aqueous solution, and this process is accelerated by exposure to oxygen, light, and elevated temperature

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It suggests either multiple pathways activated at different dose ranges or extreme potency with receptor saturation at low doses

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NCT05520775: Semaglutide for Alcohol Use Disorder Status: Underway This is an early-Phase II human trial using a randomized, placebo-controlled, dose-ranging design to investigate the effects of semaglutide, a GLP-1 receptor agonist, on alcohol-related outcomes in adults with alcohol use disorder