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Beta cell incretin receptor activity drives insulin secretion, an essential component of the antidiabetic response to either GLP-1R or GIPR agonists 10,18
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Therefore, the GLP-1-induced excitation of MCs, probably via inhibition of voltage-dependent potassium channel conductance and enhancement of glutamatergic neurotransmission, could lead to changed excitability of higher olfactory cortical as well as hypothalamic regions to change metabolic states
Literature suggests that patients lose an average of 15% of their body weight
While melanocyte stem/progenitor cells and their reservoir niche have been identified in the skin, in the oral mucosa they have not been found [6, 15]
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