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[10] It is plausible, though not yet proven specifically for retatrutide, that combined stimulation of GLP-1 and glucagon receptors could produce a more pronounced elevation in heart rate compared with single or dual agonists
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The analysis found the CRP reduction was only partly explained by weight loss and change in HbA1c, which suggests a component independent of weight loss though an exploratory analysis cannot establish a direct anti-inflammatory mechanism on its own (6)
a dual GIP/GLP-1 receptor agonist
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