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Mean percent body weight change at 80 weeks, by dose: Retatrutide 4 mg : 19.0% (47.2 lbs) Retatrutide 9 mg : 25.9% (64.4 lbs) Retatrutide 12 mg : 28.3% (70.3 lbs) Placebo : 2.2% (5.5 lbs) Responder rates at the 12 mg dose are the more interesting number for clinicians
The pen automates dosing, eliminating reconstitution and manual measurement
Deletion of IGF-1 receptors in cardiomyocytes attenuates cardiac aging in male mice
The effects of tirzepatide on body weight control have also been confirmed in non-diabetic individuals in the SURMOUNT-1 study, where treatment with tirzepatide 1015 mg was associated with an average weight loss of approximately 20% at 72 weeks, exceeding 25% in one third of the patients
Allergic reactions: Rare but possible including itching, rash, or breathing difficulties
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