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Johnson, S., & Imai, S
One review concluded that vitamin B12 plays a key role in fat metabolism, noting that a deficiency could be linked to increased fat accumulation and obesity ( Another animal study found that severe vitamin B12 deficiency led to a significant increase in body fat percentage and cholesterol levels in pregnant mice ( Whats more, one animal study showed that administering B vitamins to rats fed a high fat diet reduced weight gain and increased levels of several enzymes that influence metabolism, compared with a control group ( However, current evidence is lacking, and additional high quality studies are needed to determine how vitamin B12 may affect metabolism and body fat in humans
For a 10mg vial, adding 1mL of bacteriostatic water creates a 10mg/mL concentration that works well across the full dose escalation range from 2mg (20 units) to 8mg (80 units)
However, the improved metabolic health and reduced body weight often normalize cortisol levels that were elevated due to obesity
All potential benefits therefore must be weighed cautiously, and treatment is undertaken under medical supervision given that safety and efficacy are not yet established by regulatory authorities
