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231 In cisplatin-resistant bladder cancer, constitutive NF-B activity upregulates EMT and stemness markers, as well as ABCB1, driving resistance and progression

Another study revealed that HSP90 competitively binds to Keap1, stabilizing Nrf2, which results in the upregulation of GPX4 and promotes ferroptosis resistance in PDAC [112]

Biochem J 228:545550

The CV safety of a lower dose of liraglutide (1.8 mg, Victoza, Novo Nordisk) in people with T2D was established in the Liraglutide Effect and Action in Diabetes: Evaluation of CV Outcome Results (LEADER) study, showing a 13% reduction in major CV events over an average of 3.8 years [44]