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Immunohistochemical data of tumor tissue and previous WB results consistently showed that Bcl-2 and Ki-67 were down-regulated, while cleaved casepase-3 and Bax were up-regulated in a dose-dependent manner (Fig

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Karakousis N, Kostakopoulos NA, Georgakopoulou VE, Pyrgioti EE, Georgakopoulos PN

Future trial designs need to find a balance between inhibiting excessive inflammation and preserving anti-infection defenses, avoiding a simplistic application of pan IL-1 inhibition to all COPD patients, and instead prioritizing phased interventions for populations with high acute exacerbation frequency or high IL-1 phenotype (103) ( Figure 4 )

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