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Similar content being viewed by others Introduction G protein-coupled receptors (GPCRs) and their immediate transducersheterotrimeric G proteinshave been the subject of intensive scrutiny for decades, primarily due to their pivotal roles in innumerable physiological and pathological processes 1
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On the therapeutic side, the palmitoylation inhibitor 2-bromopalmitate (2-BP) was shown to improve MASH symptoms, which provides an experimental rationale for the development of therapeutic strategies targeting palmitoylation modifications (158)
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Each method offers distinct advantages with respect to ligand density, orientation, and liposomal stability [118,119,120]
