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In general, the combined use of vitamin B 12 and folate is more effective than either alone

There is no human safety data on combined use

Targeting the LBP Finally, drugs can be designed to bind to the ligand-binding pocket

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D: The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration