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Combining GLP-1 receptor agonists with DPP-4 inhibitors is generally not recommended due to limited additive benefit

Looking at a separate study of people with both obesity and type 2 diabetes, weight loss was understandably slightly lower diabetes medications and metabolic differences often blunt the response but still substantial

Genetic insights complement, but never replace, clinical assessment by an autoimmune specialist, current disease activity markers, and medication interactions analysis