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The pivotal trial supporting its 2010 FDA approval enrolled 816 HIV-infected adults with clinically defined lipodystrophy, and Phase 3 data documented visceral fat reductions of roughly 15-18% over 26 weeks of treatment a result robust enough to clear FDA review for a defined medical indication
Neutrophilia causes excessive ROS production that aggravates the host immunopathological response, leading to a more severe disease (Laforge et al., 2020)
Recommended to use generously to blend and even skin tone
This is one of the main reasons it is discussed as an alternative or adjunct to more familiar options such as NSAIDs
I suppose a better question is whether that prior determination should have happened at all
