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HS arises upon HF occlusion caused by hyperkeratosis, followed by inflammation, leading to the formation of subcutaneous nodules and abscesses

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In one patient with Wilson disease, elevated serum titers of anti-nuclear antibodies (ANA) were detected, accompanied by increased transaminases despite normal serum free copper levels after continuous treatment with D-penicillamine

Methotrexate can cause liver damage and decrease production of red blood cells, white blood cells, and platelets (Kozub 2011

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