difference between semaglutide and dulaglutide versus once weekly in patients with type 2 diabetes (SUSTAIN 7): a randomised, open-label, phase 3b trial Dulaglutide vs. Semaglutide For Weight

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PMID: 37717295

GLP-1 medications demonstrated notable benefits for male reproductive health and better sperm quality

Beyond interaction with lipid enzymes, our MS interactome analysis indicates that the GLP-1R binds to ERMCS-localised Sarcoendoplasmic Reticulum Calcium ATPase (SERCA) pump in the ER and voltage-dependent anion-selective channel protein 2 (VDAC2) in the OMM, both involved in calcium/ion transfer across ERMCSs 90 , suggesting a prominent role for the receptor in the control of intra-organelle ion homoeostasis, with important implications for the regulation of mitochondrial function, ER stress responses and insulin secretion 91