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As with any medication, patients may experience: Mild to Moderate Nausea: Although it causes less nausea than other GLP-1 receptor agonists, some patients may still experience this symptom, especially when starting treatment

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Starting conservatively and adjusting based on response represents the safest approach

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Regarding their metabolic effects, the combination of a GLP-1RA and a SGLT2i significantly reduces HbA1c level, body weight, and SBP, with an additive effect on weight loss and SBP but not on HbA1c [35, 57,58,59]