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These critical modifications confer a slightly higher affinity to the GLP-1 receptor for both peptides, enabling lower concentrations to achieve equivalent receptor occupancy compared to native GLP-1 [13]

Given the clinical evidence reviewed above, patients with type 2 diabetes and/or obesity are the most promising candidate population to benefit from GLP-1RA-centered pharmacotherapy to improve cardiovascular and kidney outcomes

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[Updated Jul 25, 2021]

However, there are also less common but more severe side effects, such as pancreatitis, gallbladder disease, or kidney issues, which require immediate medical attention