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Collectively, these studies suggest somewhat paradoxically that to maximize the induction of ferroptosis by GSH depletion it may be necessary to ensure that cancer cells are otherwise as metabolically active as possible

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pylori infection increases phosphohistone H2AX, a marker of repair for double-strand DNA breaks ( Figure 3 Tumor hypoxia is well recognized in oncology as a major cause of therapy resistance and poor prognosis

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