glp-1 antagonist drugs New Guidelines for Type 2 Diabetes in 2025 Transforming obesity: The advancement of

Liu YP, Shao SJ, Guo HD

GEP44 was developed based on extensive structureactivity relationship studies and earlier preliminary in vivo studies that demonstrated its greater efficacy at reducing both food intake and body weight compared to the agonist peptide, Ex-4, without triggering gastrointestinal distress (as assessed by kaolin intake and behavioral scoring as a proxy for nausea in rats and direct evidence of emesis in shrews) 16

Hyperpigmentation and Uneven Skin Tone By controlling melanin synthesis, glutathione helps reduce dark spots, tanning, and patchy pigmentation

Alpha Lipoic Acid (ALA) Both water and fat-soluble, ALA is an antioxidant made in the mitochondria

10.1126/science.1128294 Science 140 PapadopoulosV.MillerW