In POF, the ovaries lose their germinative and hormonal functions because of the exhaustion of the number of ovarian follicles before the typical age for physiological menopause which is around 50 years of age
These occur alongside shared neurodegenerative processes such as mitochondrial dysfunction, oxidative stress, and neuroinflammation
Additionally, there is a high rate of comorbidity and overlap in neural dysfunction among psychiatric disorders, as they arise from diverse and complex psychopathological factors (Sethi and Brietzke 2015)
Interestingly, LipRSV alone also reduced pup weight, suggesting metabolic effects of RSV, possibly through energy regulation and mitochondrial biogenesis (Price et al
Blood glucose and fasting insulin levels were markedly elevated in HFD-fed mice and showed a higher HOMA insulin resistance index (Fig