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If response seems inadequate after 4-6 months despite good compliance, consider protocol modifications including combination strategies with complementary peptides or topical additions
This is particularly important around bone-healing procedures such as osteotomies, where some anti-inflammatories can affect bone repair and may be avoided
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Upon zinc binding, MTF-1 undergoes a conformational change that facilitates its nuclear translocation and binding to MREs in the promoter regions of target genes [146]
However, these same trials documented various side effects that occur during the initial dose-escalation phase, including gastrointestinal symptoms and fatigue in a portion of participants
