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Increases in ACE1, or a decrease in ACE2 caused by SARS-CoV-2 in infected cells, may reflect an increased inflammatory state characteristic of severe COVID-19 (ref

2025 Jul 28;17(8):371

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In the real world, environmental toxins, your diet, stress, and other lifestyle issues have disabled the checks and balances of this system, encouraging your body to make more of the pro-inflammatory prostaglandins and less of the anti-inflammatory ones