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Materials and methods Study population Sixty PCR-confirmed SARS-CoV-2 infected individuals comprised of 30 LC patients, 15 individuals without LC symptoms who were previously infected with SARS-CoV-2 but recovered without any symptoms per se (recovered group, denoted R), 15 acute hospitalized COVID-19 patients) as well as 15 healthy controls (HCs) without acute symptoms and negative SARS-CoV-2 immunoassays ( Figure 1A , Supplementary Table 1 )
We use high-quality kefir cultures rather than conventional moulds in production to ensure the highest possible purity and quality
Regular checks are needed to adjust the treatment plan
Although we found specific examples where promoter hypermethylation co-occurs with transcriptional repression, no global correlation between differential promoter methylation and gene expression was observed
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