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That is a whopping 14 humans total

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Free radicals cause "oxidative stress," which damages cell structures and accelerates aging

In diet-induced obesity (DIO) models, NNMT loss-of-function and selective small-molecule inhibitors reduce white adipose mass and improve metabolic parameters without overt toxicity, positioning NNMT as a tractable target for metabolic-disease research [24]

But one thing to know is that NAD has been around long enoughand people have been supplementing with it for decadesthat its clear that NAD is safe