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-Hydroxybutyrate-Mediated Signaling In addition to hepatocyte synthesis of the ketone, -hydroxybutyrate (BHB), colonic bacteria also contribute to the generation of BHB

It works by inhibiting the activity of NNMT (nicotinamide N-methyltransferase) , an enzyme linked to fat cell metabolism and NAD depletion

AOD-9604 works by activating beta-3 adrenergic receptors that are highly expressed in adipose (fat) tissue but have minimal presence in appetite-regulating brain regions