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doi: 10.1038/s41551-025-01542-1 74

Beyond weight management, GLP-1 receptor agonists exhibit additional cardioprotective effects

The overlapping constipation risk deserves particular attention because severe constipation is one of the most common reasons people discontinue GLP-1 receptor agonists

Indeed, acute ganglionic blockade (Shibao et al., 2007), did not change energy expenditure in individuals with central obesity, supporting the Landsberg's hypothesis of sympathetic activation in obesity as a compensatory but ineffective strategy induced by weight gain

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