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Front Pharmacol (2022) 13:836849
This confirms that the copper is actually complexed with the peptide rather than present as a free ion or absent entirely
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Attributed to the selective IR paradox, compensatory hyperinsulinemia can amplify hyperandrogenism via several mechanisms: (i) cross-activation of insulin and/or IGF-1 receptors, which enhances LH-mediated expression of key steroidogenic enzymes (e.g., CYP17A1) in ovarian theca cells and increases androgen synthesis
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