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This theory may explain why insulin is associated with worsening in individuals who have pre-existing retinopathy where VEGF may already be playing a predominant role

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When reconstituting, inject the bacteriostatic water along the inside wall of the vial, not directly onto the powder

Medication injected into lumpy tissue may not absorb consistently, which can lead to unpredictable blood sugar levels, especially for patients who also take insulin along with GLP-1

Clinical guidance for intramuscular injections points to a 22 to 25 gauge needle, given at a 90-degree angle, with the length chosen so it reaches muscle without going too deep