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Burneo, J
One of the most common physiological changes seen is the depletion of the body's most powerful antioxidant, reduced glutathione
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Alterations of cerebral metabolism in probable Alzheimer's disease
A May 2025 study in Molecular Therapy from the INc-UAB showed that gene therapy increasing secreted klotho (s-KL) in mice extended lifespan by 15-20% while improving muscle, bone, and cognitive health at 24 months of age (equivalent to ~70 human years)
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