F., Garca-Carro, C., Puchades, M
We have unimolecular, dual agonist, tri-agonist, [and] tetra-agonists, where you can just add an alkyl group, and then you can tune GLP-1 receptor [sensitivity] up or down, says Kumar
Studies have shown that GLP-1R not only plays a role in regulating blood glucose, but is also involved in a variety of metabolic and non-metabolic processes, including inhibition of gastric emptying, appetite control, and improvement of cardiovascular function ( 3 Mechanism of action of GLP-1R in lowering blood glucose GLP-1R is expressed on pancreatic -cells, -cells and -cells and reduces blood glucose levels directly or indirectly (Figure 1A)
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