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The TB-500 component thymosin -4 is prohibited at all times under section S2 of the WADA Prohibited List (peptide hormones, growth factors, related substances and mimetics), which expressly names thymosin--4 and its derivatives
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Oral supplements require higher doses because only approximately 1% is absorbed passively when intrinsic factor is impaired, making injections the most reliable method for pernicious anaemia and malabsorption conditions
It achieves this by binding directly to GHS-R within the hypothalamus and pituitary gland and mimicking the inhibitory effect of somatostatin, leading to a surge of GH release
& Appenzeller-Herzog, C
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