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In one double-blind, placebo-controlled study, women given dietary supplements to increase glutathione levels showed a significant reduction in wrinkles and increased skin elasticity
Based on the data available in 2015, EFSA did not identify any known health risks associated with the use of dietary supplements, so no maximum dose or maximum daily intake, also known as a tolerable upper intake, was set (EFSA, 2015)
It did not report any acute adverse events in the available abstract, and the study was designed to characterise pharmacokinetics rather than to enumerate adverse effects
Therefore, oxidised glutathione should be reduced by GR again to recover its antioxidant properties, the process in which riboflavin has a key role
Bibcode:2005NYASA1057..372S
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