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Radel JA, Pender DN, Shah SA (2019) Dipeptidyl peptidase-4 inhibitors and inflammatory bowel disease risk: a meta-analysis

While some individuals may experience mild digestive side effects such as nausea, bloating, diarrhea, or constipation, these are generally uncommon and typically mild

Exposure to temperatures above 86F (30C) for extended periods can cause protein denaturation, where the molecular structure unfolds or aggregates, rendering the medication less effective or inactive

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This weight reduction persists long-term, with patients maintaining significant weight loss for up to four years