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Acknowledgements The authors express their sincere gratitude for the financial support provided by the Deanship of Graduate Studies and Scientific Research at Jazan University, Saudi Arabia, under project number JU- 202502113 -DGSSR- RP -2025
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Our functional and structural data, along with molecular dynamics (MD) simulations, suggest that receptor conformational dynamics associated with flexibility of the peptide N-terminal activation domain may be a key determinant of agonist efficacy
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Studies of GLP-1 receptor agonists demonstrate that medication persistence correlates strongly with both glycemic control and weight loss success
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