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In triple-negative breast cancer (TBNC), TMAO induced pyroptosis in tumor cells by activating the endoplasmic reticulum stress kinase PERK, enhanced CD8 T cell-mediated antitumor immunity in vivo, and correlated with improved efficacy of immunotherapy [178]
Se explicara por cambios asociados a la inhibicin de la reabsorcin tubular de Na+que resultan en disminucin de la presin intraglomerular y por tanto de la hiperfiltracin que es uno de los principales mecanismos responsables de la nefropata DM102,104,121
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It has a profound protective and healing effect on the gut lining
In addition, -KG can be utilized via malic enzyme to generate NADPH, a process that supports glutathione regeneration (Martnez-Reyes and Chandel, 2020)
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